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Intersex people are born with sex characteristics, such as chromosomes, gonads, or genitals that, according to the UN Office of the High Commissioner for Human Rights, "do not fit typical binary notions of male or female bodies".A sex and gender distinction is not universal, and Peletz's description of gender as designating biological variations as well as cultural practices is not unique.Gender may be organized differently in different cultures.In some non-Western cultures, gender is not binary and one can cross freely between male and female.In a study of arguments that intersex people fit into a third gender classification, intersex scholar Morgan Holmes argues that much analysis of a third sex or third gender is simplistic: much of the existing work on cultural systems that incorporate a 'third sex' portray simplistic visions in which societies with more than two sex/gender categories are cast as superior to those that divide the world into just two.

To the Indigenous Māhū of Hawaii, it is an intermediate state between man and woman, or to be a "person of indeterminate gender".

In March 2017, an Australian and Aotearoa/New Zealand community statement called for an end to legal classification of sex, stating that legal third classifications, like binary classifications, were based on structural violence and failed to respect diversity and a "right to self-determination".

It also called for the criminalization of deferrable intersex medical interventions.

The term third is usually understood to mean "other"; some anthropologists and sociologists have described fourth, genders.

Biology determines whether a human's chromosomal and anatomical sex is male, female, or one of the uncommon variations on this sexual dimorphism that can create a degree of ambiguity known as intersex.

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A sex/gender system which recognizes only the following two social norms has been labeled "heteronormative". Peletz believes our notions of different types of genders (including the attitudes toward the third gender) deeply affect our lives and reflects our values in society.